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Searle Laboratories developed Anavar in the 1960s to help regrow muscle in patients with diseases that cause involuntary weight loss. The drug is now available worldwide through the U.S. National Institutes of Health in the form of a transdermal patch and in France through the European Society for Human Genetics. In addition to improving blood circulation and maintaining muscle strength, the patch can be used to manage diabetes. After injection, the patch is applied to the skin, where it lasts for up to six months. The patch can also be used as a medication and in the past was used a number of times per week. When an injury occurs and no longer offers any improvement, a person could opt to receive an intravenous injection of the drug. Injectors such as Humira, Humotransfer and Anavar have a limited shelf life and if the patch is left in contact with the skin for a long time, the skin cells inside the capillaries become dehydrated and lose their ability to absorb nutrients. In the case of Anavar, that means the injections lose effectiveness and patients need to undergo repeated injections or a skin graft to maintain their current levels of muscle mass. Researchers are also assessing whether skin grafts may provide a way to treat a variety of conditions, including muscle atrophy and muscular dystrophy. Although Anavar is a relatively new drug, it's becoming increasingly popular with healthcare providers, who cite a number of studies that show its safety. However, researchers have not yet studied the long-term effects of the drug on human beings. The study published in the journal Clinical Endocrinology & Metabolism, co-authored by G.N. Dominguez of Searle in Philadelphia, was limited to male patients over 40 years old with a history of type 2 diabetes who had been on insulin for six months. The average patient was on the patch for six months. After five days of administration, the patients reported that they didn't feel any worse but that some of their muscles had become swollen. For the rest of the patients, only a tiny amount of the skin had changed as shown in the graph below. The researchers concluded that Anavar's benefit is associated with its efficacy and that the average patient may still be expected to benefit from the drug. The study was supported by NIH grants R01AI095832 and P50DK075841 Similar articles: